METHOD FOR DETECTING ANALYTE USING SURFACE ENHANCED RAMAN SPECTROSCOPY, BIOSENSOR, AND METHOD OF MANUFACTURING THEREOF

摘要

A method for detecting one or more analytes using surface enhanced Raman spectroscopy (SERS) is provided. The method includes a) providing a SERS-active substrate having at least one metal carbonyl cluster compound covalently attached thereon; b) contacting one or more analytes with the at least one metal carbonyl cluster compound; and c) detecting changes in surface enhanced Raman signal from the at least one metal carbonyl cluster compound as an indication of the presence of the one or more analytes. A biosensor for the detection of an analyte using SERS and method of manufacturing the biosensor are also provided.