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METHODS OF INHIBITING IGF-1R ACTIVATION OR DOWNTREAM SIGNALLING THEREOF TO REDUCE RADIATION-INDUCED CELLULAR SENESCENCE
METHODS OF INHIBITING IGF-1R ACTIVATION OR DOWNTREAM SIGNALLING THEREOF TO REDUCE RADIATION-INDUCED CELLULAR SENESCENCE
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机译:抑制IGF-1R激活或下游信号的方法以减少辐射诱导的细胞衰老
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摘要
Accelerated senescence has been shown to occur as a primary response to cellular stresses including DNA damaging agents (e.g., ionizing radiation) and is widely believed to be caused by continuous proliferative signaling in the presence of cell cycle arrest. The present disclosure provides a method of reducing cellular senescence in non-cancerous cells following exposure to ionizing radiation.
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