METHODS AND COMPOSITIONS FOR THE INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY AND VASCULAR PERMEABILITY

摘要

Methods of altering microenvironmental levels of Vascular Endothelial Growth Factor in a subject are disclosed. The methods include providing a Granzyme B (GzmB) inhibitor to an area of inflammation. The area of inflammation can be associated with conditions that have an associated increase in vascular permeability, including for example, rheumatoid arthritis, myocardial infarction, ocular disease, skin conditions, such as psoriasis, and dermatitis, cancer, transplantation, and/or arthrosclerosis, and the like. The Granzyme B inhibitor can be comprised of, but not limited to, a nucleic acid, a polypeptide, a Granzyme B specific antibody, a Granzyme B antibody derivative, or a small molecule.