首页> 外国专利> ENANTIOMERS OF FLUCONAZOLE ANALOGUES CONTAINING THIENO-2,3-D PYRIMIDIN-4(3H)-ONE MOIETY AS ANTIFUNGAL AGENTS

ENANTIOMERS OF FLUCONAZOLE ANALOGUES CONTAINING THIENO-2,3-D PYRIMIDIN-4(3H)-ONE MOIETY AS ANTIFUNGAL AGENTS

机译：包含硫杂环丁[[2,3-D]嘧啶-4（3H）-部分作为抗真菌剂的氟康唑类似物的对映体

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摘要

The present invention discloses novel enantiomeric antifungal compounds of Formula (1a) and Formula (1b) containing thieno-[2,3-d]Jpyrimidin-4(3H)-one moiety and pharmaceutically acceptable salts thereof, method of preparing these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these compounds.

机译：本发明公开了新的式（1a）和式（1b）的对映体抗真菌化合物，其包含噻吩并[[2，3-d] py嘧啶-4（3H）-一个部分及其药学上可接受的盐，其制备方法，这些化合物在预防和治疗真菌感染中的用途，以及含有这些化合物的药物制剂。

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公开/公告号EP2709625A1

专利类型
公开/公告日2014-03-26

原文格式PDF
申请/专利权人 FDC LIMITED;COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH;
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申请/专利号EP20110740992
发明设计人 BORATE HANUMANT BAPURAO;SAWARGAVE SANGMESHWER PRABHAKAR;CHAVAN SUBHASH PRATAPRAO;CHANDAVARKAR MOHAN ANAND;IYER RAMKRISHNAN RAMACHANDRAN;NAWATHYE VIKAS VASANT;CHAVAN GAJANAN JALINDAR;TAWTE AMIT CHANDRAKANT;RAO DEEPALI DAMODAR;MAUJAN SULEMAN RIYAJSAHEB;
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申请日2011-05-31
分类号A61K31/519;C07D495/04;
国家 EP
入库时间 2022-08-21 15:46:19

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2. Efficient Synthesis of 2-Substituted Quinolino7', 8':5, 6pyrano-2, 3-dpyrimidin-4(3H)-ones via Tandem Aza-Wittig Reaction [J] . FANG Zheng-dong, WANG Guo-hong, WANG Dun-jia 高等学校化学研究（英文版） . 2009,第006期

3. Efficient Synthesis of 2-Substituted Quinolino7＇, 8＇：5, 6pyrano2, 3-dpyrimidin-4（3H）-ones via Tandem Aza-Wittig Reaction [J] . FANG Zheng-dong, WANG Guo-hong, WANG Dun-jia 高等学校化学研究：英文版 . 2009,第006期

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2. Synthesis and Crystal Structure of 2-Ethoxy-3-n-butyl-benzofuro2,3-dpyrimidin-4（3H）-one [J] . HU Yang-Gen ,DING Ming-Wu . 结构化学 . 2008,第001期

3. 苯并4',5'噻吩并3',2':5,6吡啶并4,3-d嘧啶-4(3H)-酮的合成与杀菌活性研究 [C] . 任青云 ,贺红武 ,刘建超 . 中国化工学会农药专业委员会第十二届年会 . 2005

4. 取代苯氧乙酰硫脲及其稠杂环的研究---含嘧啶杂环的取代苯氧乙酰硫脲和2H-1,2,4-噻二唑并[2,3-a]嘧啶衍生物的合成及除草活性研究 [A] . 郭金山 . 1999