Method for controlling differentiation of stem cell using human H3K79 methyltransferase Dot1L

摘要

The invention genome (genome) level of pluripotency-associated genes in the expression regulation of factor hDot1L (Disruptor of telomeric silencing like) for using stem cell differentiation control method in related to, more particularly hDot1L the intracellular level adjustment It relates to a composition for inhibiting or promoting stem cell differentiation comprising the method and hDot1L expression or over-expression vector inhibitor to change the multipotent stem cells as active ingredients. hDot1L of the present invention is to control the expression of pluripotency-associated genes regulates the pluripotent stem cells. Thus, the method of the present invention to adjust by means of inhibiting or promoting cell level within the hDot1L have the effect to regulate the differentiation of stem cells. ;