CORE CROSS-LINKED POLYMERIC MICELLE FOR DRUG DELIVERY AND METHOD OF MANUFACTURING THE SAME

摘要

PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and polyN-2-(hydroxypropyl)methacrylamide. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.