Solid Pena god or a salt thereof stable particulate pharmaceutical composition

摘要

The present invention provides a method for Solidarity Pena god or a salt formulation in clinical practice , suitable for coating spherical , yet also relates to the provision of stable renal Pena Solid particulate pharmaceutical composition or the salt thereof which can suppress the decomposition with time . More particularly , in the formulation of Solid particulate compositions divine Pena , Tg or mp relates to a particulate pharmaceutical composition that can be obtained by using the binder is less than 174 . Further , by adding a crystallization promoting treatment after preparation of the particulate pharmaceutical composition , may provide a more stable sour or salt Pena Solid particulate compositions .