COMPOSITION INHIBITING FORM CELL FORMATION COMPRISING SERUM AMYLOID A SYNTHESIS INHIBITORS OR FORMYL PEPTIDE RECEPTOR 2 ACTIVITY MODULATORS

摘要

The present invention relates to a pharmaceutical composition for inhibiting foam cell formation containing serum amyloid A synthesis inhibitors or formyl peptide receptor 2 activity modulators, and a method of preventing and treating atheriosclerosis. The formation of foam cells can be effectively inhibited by using the composition of the present invention. During the foam cell formation inhibition, the composition does not affect a pertussis toxin sensitive G protein dependent signaling pathway and is capable of minimizing side effects. The foam cell formation is a critical phase of the etiology of the atheriosclerosis. Therefore, the composition of the present invention is expected to be significantly applied to the prevention and treatment of diseases related to the foam cell formation including atheriosclerosis.