BIOCOMPATIBLE SMALL INTESTINAL SUBMUCOSA SHEET HAVING ADJUSTABLE IN VIVO DEGRADATION TIME AND METHOD FOR PREPARING SAME

摘要

The present invention provides a biocompatible small intestinal submucosa sheet having adjustable in vivo degradation time in which the small intestinal submucosa of an animal reacts with a crosslinking agent to form a crosslinked bond. The present invention also provides a method for preparing the biocompatible small intestinal submucosa sheet. The biocompatible small intestinal submucosa sheet according to the present invention may delay in vivo degradation time by the crosslinked bond of the crosslinking agent, and may adjust the degradation time depending on the degree of formation of the crosslinked bond based on the type of the crosslinking agent and crosslinking time. Therefore, the biocompatible small intestinal submucosa sheet according to the present invention can be significant and valuably used as a scaffold for tissue engineering, a drug carrier, wound dressing or an antihemorrhagic agent.;COPYRIGHT KIPO 2014;[Reference numerals] (AA) 6 hours; (BB) 12 hours; (CC) 24 hours; (DD) 48 hours; (EE) 60 hours