Preparation and Biocompatibility of a Novel Scaffold Made from Small Intestinal Submucosa Powders

摘要

Three-dimensional porous scaffolds play a critical role in both cell targeting and cell transplantation strategies.Small intestine submucosa (SIS) has been recommended as a cell-free,biocompatible and with minimum immune response biomaterial.However,the three-dimensional structure of SIS isn’t very suit for tissue regeneration and tissue engineering.So,we tried to prepare SIS sponges and got a kind of novel scaffold.Scanning electron microscope showed that SIS sponge had interconnected network structure and comparably regular pore.The pore diameter was around 100–150μm.In vivo implantation test,the sponges were implanted in dorsal muscle of rats for 4 weeks and the results suggest that the SIS sponges had good biocompatibility and also could completely degrade in vivo.So we conclude that the SIS sponges maybe are available scaffolds for injury repair.