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ENZYME-RESPONSIVE GRAPHENE OXIDE/BIOPOLYMER-PHOTOSENSITIZER NANOCOMPLEX AND COMPOSITION FOR FLUORESCENCE IMAGE AND PHOTODYNAMIC/PHOTOTHERMAL TREATMENT COMPRISING THEREOF
ENZYME-RESPONSIVE GRAPHENE OXIDE/BIOPOLYMER-PHOTOSENSITIZER NANOCOMPLEX AND COMPOSITION FOR FLUORESCENCE IMAGE AND PHOTODYNAMIC/PHOTOTHERMAL TREATMENT COMPRISING THEREOF
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机译:酶促氧化石墨烯/生物聚合物-光敏剂纳米复合物及其组成,用于荧光图像和光热/光热处理
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摘要
The present invention relates to a nanocomplex in which the fluorescence and reactive oxygen generation are activated by the action of a specific enzyme overexpressed in cancer cells, and more specifically, to a graphene oxide/biopolymer-photosensitizer nanocomplex for a cancer cell selective fluorescence image or photothermal treatment which is obtained by combining graphene oxide to a responsive binder. The graphene oxide/biopolymer-photosensitizer anocomplex according to the present invention selectively reacts to an enzyme expressed in the cancer cells and generates a strong fluorescence signal, and generates reactive oxygen species and heat. Therefore, the graphene oxide/biopolymer-photosensitizer anocomplex according to the present invention can be applied to not only the fluorescence image diagnosis but also the photodynamic/photothermal treatment of cancer. [Reference numerals] (AA,BB) Light; (CC) Biopolymer-photosensitizer binder; (DD) Graphene oxide
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