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GRAFTED CONJUGATES OF POLYSACCHARIDES AND SIRNAS, SIRNA DELIVERY SYSTEM COMPRISING THE SAME AND PREPARING METHOD THEREOF
GRAFTED CONJUGATES OF POLYSACCHARIDES AND SIRNAS, SIRNA DELIVERY SYSTEM COMPRISING THE SAME AND PREPARING METHOD THEREOF
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机译:多糖和siRNA的嫁接结合物,包含相同成分的siRNA递送系统及其制备方法
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摘要
The present invention relates to polysaccharides derivatives in which siRNA is grafted, a gene carrier comprising the same, and a method for manufacturing the same. In the siRNA carrier according to the present invention, since polysaccharides is located on the surface of the carrier, the dispersion stability is high so the siRNA carrier can be stable in the body for a long time without aggregation, thereby effectively suppressing the protein expression of a target gene, and the siRNA can be easily restored into the original structure of siRNA having a bioactivity in the cell after entering the body. Also, the present invention dramatically improves therapeutic effects by introducing functional molecules appropriate for target therapies according to various target diseases using the polysaccharides functional group located on the surface of the siRNA carrier, thereby being able to be used in various fields of gene therapy using siRNAs.
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