Asymmetric reduction of coumarins, intermediates synthesized therefrom and its applications

摘要

The present invention relates to intermediates and their utilization for coumarin derivatives that are generated from the asymmetric reduction and the reaction through the asymmetric hydrogenation reaction. In the present invention, copper-containing catalyst, a ligand and by the addition of pinacol borane as a reducing agent may reduce the coumarin derivative to stereoselectively, by utilizing the boron enol rate (boron enolate) intermediate of the reduction reaction the same as the electrophile reaction in a reaction vessel was added to the reaction vessel in a simplified compared with the conventional can be obtained intermediate having the stereocenter of the various parts, the obtained intermediate can be used as intermediates for the preparation of various medicinal compounds.