The present invention relates to tau protein hyperphosphorylation Chemical inhibitor containing as an active ingredient, pentoxy pilrin , the pentoxy pilrin is used to prevent or treat a primary dementia , such as the increase in LDH release , superphosphate increased anger and neuronal dendrites damage of tau protein by Okada prevented by acid treatment of Alzheimer's dementia , Parkinson's dementia and frontotemporal dementia sex as can be very useful to . ; 展开▼