Novel cyanine derivatives having meso-reactive functional group at polymethine chain and preparation method thereof

摘要

The present invention mezzo in polymethine chain - reaction novel cyanine derivatives with functional groups and relates to a preparation method thereof , cyanine derivatives substituted in the meso position is reacted functional groups according to the invention is very simple and suitable for mass production by this synthesis method, a reagent for detecting nerve agents subjected to a conventional two-step reaction process of and cyanine derivatives of the present invention , on the other hand , so that the course of the reaction through only one step of the reaction rate is very fast and also excellent sensitivity , and therefore can be active in the pH of the acid can also be used in an aqueous environment , the pH of the acidic activation measured as ratio may be useful in the near-infrared probe (acid pH-activatable ratiometric NIR probe). ;