A process for preparing high purity of ⒮Metoprolol

摘要

The present invention relates to a method for manufacturing (S)-metoprolol which is used as a depressant, and more specifically, to a novel method for effectively manufacturing high purity (S)-metoprolol, comprising the steps of: carrying out a condensation reaction of (R)-epichlorohydrin and 4-(2-methoxyethyl) phenol, which are starting materials, by using a chiral salen catalyst under a very mild condition in which racemization is suppressed; carrying out an epoxidation reaction in the presence of a base; and carrying out a condensation reaction with isopropyl amine.