Composition for enhancing TRAIL sensitivity comprising inhibitors for expression or activity of TIP４１ as a target gene of TRAIL sensitizer

摘要

The present invention relates to a composition for increasing TRAIL sensitivity, which contains an inhibitor for inhibiting the expression or activity of the TIP41 protein. More particularly, it has been found that, when a hepatocellular carcinoma cell line which has TRAIL tolerance is treated with TIP41 siRNA and TRAIL, carcinoma-cell-specific apoptosis is induced, and apoptosis is induced not only in liver cancer but also in lung cancer and colorectal cancer which have TRAIL tolerance, and it has been found that, through animal experimentation, the size of a tumor is reduced and cancer cell apoptosis is induced, and the thus-induced apoptosis is caused by the activation of the MKK7/JNK delivery pathway due to the inhibition of TIP41 expression.; Therefore, the composition containing the inhibitor for inhibiting the expression or activity of the TIP41 protein according to the present invention can be valuably used in the prevention and treatment of cancer or as anticancer adjuvants.