Novel Hydroxamic Acids Having Histone Deacetylase Inhibiting Activity and Anti-Cancer Composition Comprising the Same As An Active Ingredient

摘要

The present invention provides novel hydroxamic acid compounds, and which contain the active ingredient in the anti-cancer pharmaceutical composition for the relates . Hydroxamic acid compound of the present invention has the inhibitory activity of the histone deacetylase (histone deacetylase, HDAC), expressed in a variety of cancer cells , so the cytotoxicity exhibited antitumor efficacy , may usefully be used as a powerful anti-cancer agents .