Sensitive MRI Contrast Nano Agents Based Ionic Complex Containing Anionic and Cationic Polymer and Preparing Method Thereof

摘要

The present invention relates to nanocomposites and methods for their preparation containing anionic and cationic polymers, bio-compatible polymer material of poly-gamma-glutamic acid ( -PGA) and by using the ionic self-assembly properties of chitosan prepared by encapsulating the iron oxide-based nanoparticles with -PGA / chitosan polymer composite interior of poly-gamma-glutamate ( -PGA ) / chitosan / relates to a composite and a method of manufacturing a manganese iron oxide nanoparticles. Anionic poly-gamma-glutamate ( PGA) and iron oxide-based nanoparticles with an ionic assembly using cationic chitosan according to the invention is iron oxide-based nanoparticles trapped in the complex internal sealed inside a polymer composite due to the interaction between each other Since synergy induced MR signal amplification, one has the characteristic that the excellent contrast effect than when present in a particle. ;