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High-sensitivity magnetic resonance imaging nano-contrast agent based on an anionic polymer and cationic polymer ion complex, and a production method therefor
High-sensitivity magnetic resonance imaging nano-contrast agent based on an anionic polymer and cationic polymer ion complex, and a production method therefor
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机译:基于阴离子聚合物和阳离子聚合物离子络合物的高灵敏度磁共振成像纳米造影剂及其制备方法
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摘要
The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.;The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.
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