Hollow Microneedle for Intravitreal Drug Delivery

摘要

The present invention comprises the steps of: (a) applying a solution of the viscous material on the substrate surface; (B) contacting the solution with a syringe needle as a frame of said viscous material; (C) the substrate so that the substrate is spaced apart from the contact with a syringe needle, syringe needle, or the substrate lifting the needle and syringe by preparing a solid microstructures; (D) comprising a metal deposited on the solid microstructures; (E) a step of plating the metal of the metal-deposited solid microstructures; (F) the steps of the cutting bevel of the tip of the metal-plated solid microstructures; The bevel angle is given by the bevel cutting is 5 ^o -20 ^o , (g) a step of obtaining a hollow micro-structure by removing the solid microstructures Intravitreal comprising (intravitreal) provides a process for the preparation of injectable hollow microneedle. Intravitreal use state of the present invention, the hollow micro-structure it is made of metal membrane and the strength or the power to pass through the retina. Intravitreal injectable hollow microstructures of the present invention has got a super high aspect ratio, it is possible to minimize damage to the retina. Intravitreal injectable hollow microstructures of the present invention to be an effective length sufficient to deliver medication to the eye center may increase the effectiveness of the drug. Intravitreal injection hollow micro-structure of the present invention are readily available and is compatible with a normal syringe. ;