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Method for producing induced pluripotent stem cell using intercellular protein delivery

机译:利用细胞间蛋白传递产生诱导多能干细胞的方法

摘要

The present invention inducer of cell de-differentiation of stem cells in my introduction Ho Meo domain as secreted proteins using the amino acid sequence of a method for producing a de-differentiation of stem cells by the relative variations of the electron efficiency, is secreted into the extracellular secretion that can be moved into the surrounding cell-associated region of infiltration and de-differentiation inducer hayeoteumeuro producing the de-differentiation of stem cells from somatic cells by the target de-differentiation inducer secreted from the transformed cell prepared by the transformed cell to express the fusion protein it co-culture with differentiated somatic target, the fuse of the present invention The gene constructs and transgenic cells expressing this encoding the protein may be useful in preparing the de-differentiation of undifferentiated stem cells from differentiated somatic cells. ;
机译:在本发明的引入Ho Meo结构域中作为分泌蛋白的干细胞去分化诱导剂,是利用通过电子效率的相对变化产生干细胞去分化的方法的氨基酸序列而分泌的。细胞外分泌物可移入周围细胞相关的浸润和去分化诱导剂hayeoteumeuro区域,通过转化细胞制备的转化细胞分泌的目标去分化诱导剂,从体细胞中产生干细胞去分化为了表达其与分化的体细胞靶标共培养的融合蛋白,本发明的融合体。表达该蛋白的基因构建体和转基因细胞编码该蛋白可用于制备未分化的干细胞与分化的体细胞的去分化。 ;

著录项

  • 公开/公告号KR101456998B1

    专利类型

  • 公开/公告日2014-11-05

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20120040983

  • 发明设计人 레 다이;김진우;알란 프로시앙;

    申请日2012-04-19

  • 分类号C12N15/62;C12N15/867;C12N5/10;C12N5/0735;

  • 国家 KR

  • 入库时间 2022-08-21 15:39:48

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