METHOD FOR PRODUCING validity Molecular genetic models for preclinical testing of new antiepileptic DRUGS

摘要

A method for producing one of the common molecular genetic model for preclinical testing of new antiepileptic drugs, consisting in that with help of genotyping locus Taq 1A DRDsredi rats WAG / Rij identified parent individuals P with genotype A / Agen DRD, hybridize with each other to give progeny F which are grown to sexual maturity age, then among the offspring individuals Fvydelyayut neaudiogennyh then neaudiogennyh offspring individuals Fskreschivayut together to produce offspring F, which is then also oraschivaetsya to sexually mature age, among them also are selected neaudiogennyh individuals, thus crossing and selection is performed repeatedly to obtain a homogeneous population neaudiogennyh rats WAG / Rij lines with genotype A / Agen DRD, moreover, the control type TAPs in selected individuals progeny F to subsequent crossbreeding produced by electroencephalographic analysis including morphological control.