SYNTHESIS METHOD Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NH2

摘要

1. A method for the synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase comprising fragmentov.2 condensation technique. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase of claim 1, wherein a protected aminokisloty.3. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase of claim 2 wherein said protected amino acids are selected from the group consisting of amino, protected Boc , amino acids, protected benzyloxycarbonyl, amino acids, Fmoc-protected and protected fluoroanhydrides aminokislot.4. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to claim 3, wherein said protected amino acid fluoride is a fluoride or fluoride Fmoc amino Bsmoc amino acids. 5. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to any of claims 1-4, wherein the mixed crosslinking technique angidrida.6 applied. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to any of claims 1-4, wherein the method is used crosslinking gidrazida.7 peptide. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to any of claims 1-4, wherein for the conversion of an ester functional group to an amide functional group applicable ammiak.8. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to any of claims 1-4, wherein use protected peptide fragment Trp-Cys or Arg- Trp.9. A method of synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to claim 8, wherein said protected peptide fragment Trp-Cys represents Boc-Trp-Cys (Acm) -OMe or Boc-Trp (For) -Cys (Acm) -OMe.10. Synthetic Process Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHv liquid phase according to claim 8, wherein the peptide fragment used protected D-Ala-His or His-D- Phe.11. Synthetic Process Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) Ms -NHv