ACT ACTIVITY INHIBITORS

摘要

1. The compound of formula (I):, in which: each R and R are independently selected from hydrogen, aryl, C-C1-6 alkyl, CN, CHO, COH, CONH, CONHR, CONRR, COR, COR, NH, NHR, NRR, NHCOR, NHSOR , NRCOR, NRSOR, OH, OR, SH, SR, SOR, SOR, SONHR, SONRR, F, Cl, Br and I, where each R, R and R are independently selected from C-C 1-6 alkyl, including the cases when R and R together with a nitrogen atom to which they are attached form a heterocycle; where the individual R and R together with the carbon atom to which they are attached can form an optionally substituted and optionally saturated heterocycle or carbocycle; or R and R together represent oxo or optionally C-Calkyl O-substituted oxime; W represents O, S, SO, SO, NR 'or CRR, where R' is either hydrogen or C-Calkyl, and where each R and R are independently selected from the above group from which R and R are selected; X is either absent or represents CRR, where each R and R are independently selected from the above group from which R and R are selected; Y and Z independently represent either substituted or unsubstituted nitrogen or carbon, and where carbon is substituted fuels independently selected from the representatives of the above group from which R and R are selected, or in the case of nitrogen, the substituent is selected from aryl, C-C1-6 alkyl, SOR, CONHR, CONRR, COR and COR, where R, R and R are as defined above, or where Y and Z together form an optionally substituted heterocyclyl or carbocyclic group, or where Y is SO; R and R are independently selected from H and alkyl, including the cases when R and R together with the nitrogen atom to which they are attached form a heterocycle; and R and R are independently selected from H, (C-C) alkyl, (C-C) alkenyl, and (C-C) alkynyl, wherein said alkyl is optionally substituted with no more than three batches