SUBSTITUTED DIHYDROPIRAZOLES FOR THE TREATMENT OF CARDIOVASCULAR AND HEMATOLOGICAL DISEASES, THEIR APPLICATION, MEDICINE AND METHOD OF TREATMENT AND / OR PREVENTION

摘要

1. The compound of formula (I) in which R represents a heteroaryl group of the formulas, or, in which * means the connection with the dihydrolyrazole ring, A for each individual manifestation means C-R or N, with a maximum of two members of cycle A simultaneously mean N, IE denotes O, S or NR, R denotes a heteroaryl group of the formulas ,,,,,,,,,,, or, in which # means the junction with the dihydropyrazolone ring, G means for each individual occurrence of C-R or N, with a maximum of two members cycle G simultaneously mean N, and J means O, S or NR, and L means for each single C-R or N occurrence, with a maximum of two members of the cycle L simultaneously denoting N, where R, R and R are the same or different and in each case independent of each other and mean hydrogen or substituents selected from the group consisting of halogen, cyano, nitro, (C-C) -alkyl, (C-C) -cycloalkyl, 4-10 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, -C (= O) -R, C (= O) -OR , -C (= O) -NRR, -OC (= O) -R, -OC (= O) -NRR, -NR-C (= O) -R, -NR-C (= O) -OR, -NR-C (= O) -NRR, -NR-SO-R, -SO-R, -SO-NRR, -OR, -SR and -NRR, where (i) (С-С) -alkyl, in its a queue may have from one to three substituents, identical or different, chosen data from the group consisting of halogen, cyano, oxo, (C-C) -cycloalkyl, 4-10 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, -C (= O) -R, -C (= O) -OR, -C (= O) -NRR, -OC (= O) -R, -OC (= O) -NRR, -NR-C (= O) -R, -NR-C (= O) - OR, -NR-C (= O) -NRR, -NR-SO-R, -SO-R, -SO-NRR, -OR, -SR and -NRR, while the last named cycloalkyl, heterocycloalkyl, phenyl and heteroaryl residues , in turn, can accordingly have from one to three substituents, identical or different, from the group consisting of, halogen, cyano, (C-C-alkyl, trifluoromethyl, hydroxy, (CC) -alkoxy, trifluoromethoxy, oxo, amino, mono (C-C) -alkylamino, di- (C-C)