SIGMA LIGANDS FOR POTENTIATION OF ANALGETIC EFFECT OF OPIOIDS AND OPIATES IN POSTOPERATIVE PAIN AND TO REDUCE THE DEPENDENCE ON THEM

摘要

1. A combination for simultaneous, separate or sequential administration, comprising at least one sigma ligand of the formula (I), or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, and at least one opioid or opiate intended for the prevention and / or treatment of pain resulting from surgery, where R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR, -C (O) NRR, -CH = NR, -CN, - OR, —OC (O) R, —S (O) —R, —NRR, —NRC (O) R, —NO, —N = CRR or halogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted, aroma heterocyclyl substituted or unsubstituted heterocyclylalkyl, -COR, -C (O) OR, -C (O) NRR, -CH = NR, -CN, -OR, -OC (O) R, -S (O) -R, -NRR, -NRC (O) R, -NO, -N = CRR or halogen; R and R are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl substituted or unsubstituted arylalkyl, substituted or unsubstituted, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted heterocyclylalkyl