Sigma ligands for the potentiation of the Analgesic effect of opioids and opiates in the postoperative pain and the Attenuation of the unit with the same

摘要

A combination including sigma formula (1) ligation and opiates or opiates for the prevention and / or treatment of pain caused by surgery, especially marginal neuralgia, alodine, causal pain, hypertension, hypertension, hypertension, nerve failure, Neurological or neurological disorders: sigma formula ligation (1) for enhancing the analgesic effect of opiates or opiates and / or reducing opiate dependence,When opiates or opiates are used to prevent and / or treat pain due to surgery, requirement 1: is used in combination for simultaneous, separate or sequential management, including at least one formula sigma match (1),or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, and at least one opioid or opioid, for use in the prevention and / or treatment of pain developed as a result of surgery in which R1 is selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, aromatic or unsubstituted heterocyclyl, substituted or unsubstituted, substituted or unsubstituted heterocyclyl alkyl , -COR8, -C (O) OR8, -C (O) NR8R9, -CH = NR8, -CN, -OR8, -OC (O) R8, -S (O) t-R8, -NR8R9, -NR8C (O) R9, -NO2, -N = CR8R9,Or halogen; R2 is selected from hydrogen, substituted or unsubstituted tar, substituted or unsubstituted cyclopentyl compound, substituted or unsubstituted Halon, substituted or unsubstituted arilalquilo, aromatic or non aromatic isocyclohexane, substituted or unsubstituted components, Propylpropylpropylpropylpropylpropylpropylpropylpropyl Substituted or unsubstitutedsubstituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, aromatic or non-aromatic heterocyclyl, substituted or unsubstituted, substituted or unsubstituted heterocyclyl alkyl, -COR8, -C (O) OR8, -C (O) NR8R9, -CH = NR8 , -CN, -OR8, -OC (O) R8, -S (O) t-R8, -NR8R9, -NR8C (O) R9, -NO2, -N = CR8R9, or halogen, or together form a system of condensed rings optionally substituted; R5 and R6 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, aromatic or non-aromatic heterocyclyl,substituted or unsubstituted, substituted or unsubstituted heterocyclylalkyl, -COR8, -C (O) OR8, -C (O) NR8R9, -CH = NR8, -CN, -OR8, -OC (O) R8, -S (O ) t-R8, -NR8R9, -NR8C (O) R9, -NO2, -N = CR8R9, or halogen; or together they form, with the nitrogen atom to which they are attached, an aromatic or non-aromatic, substituted or unsubstituted heterocyclyl group; n is selected from 1, 2, 3, 4, 5, 6, 7 or 8; t is 1, 2 or 3; R8 and R9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, aromatic or non-aromatic, substituted or unsubstituted heterocyclyl,Substituted or unsubstituted oxy group, substituted or unsubstituted oxy group or halogen. 11. Claim 10: a combination of a group of opiates or opiates consisting of morphine, tramadol, sufentanil, remifentanilo, Fentanil, tapendadol, oxycodone, buprenorphine or similar substances, in accordance with any of the above requirements.