MADE OF MICRO-NEEDLE ARRAYS AND METHOD FOR FORMING MICRO-NEEDLE ARRAYS

摘要

1. A method of forming an array of microneedles, including the introduction of plastic material into the cavity of a negative imprint of a microneedle, wherein the cavity of a negative imprint of a microneedle forms many manufactured nanostructures on the surface, and the nanostructures are arranged in a pattern. The method according to claim 1, which further comprises combining the first segment of the mold with the second segment of the mold, the first segment of the mold containing the first segment of the microneedle, and the second segment of the mold containing the second segment of the microneedle, while combining the first and between the second segments of the mold, a cavity of a negative microneedle imprint is formed between them, and the first and second segments of a microneedle form part of the cavity of a negative imprint of a microneedle. 3. The method according to claim 1 or 2, wherein the cavity of the negative imprint of the microneedle forms a mold of the microneedle channel. The method according to claim 1 or 2, further comprising combining the base with the negative microneedle cavity to form a cavity in the substrate adjacent to the negative microneedle cavity. The method according to claim 1 or 2, further comprising forming a positive cast mold. The method according to claim 1 or 2, further comprising heating the cavity of the negative imprint of the microneedle before introducing plastic material into the cavity of the negative imprint of the microneedle. The method according to claim 1 or 2, in which the plastic material is a polymeric material. The method according to claim 1 or 2, wherein the plastic material is inserted into the negative microneedle cavity under a pressure of greater than about 6000 psi. The method according to claim 1 or 2, further comprising