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ORAL PHARMACEUTICAL COMPOSITION DIURETIC AND ACE INHIBITOR IN MICRONIZED FORM, MEDICINAL PRODUCT AND ITS APPLICATION
ORAL PHARMACEUTICAL COMPOSITION DIURETIC AND ACE INHIBITOR IN MICRONIZED FORM, MEDICINAL PRODUCT AND ITS APPLICATION
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机译:微粉化形式,药物产品的口腔药物组合物利尿剂和ACE抑制剂及其应用
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1. An oral pharmaceutical composition containing a combination of a diuretic and an ACE inhibitor, characterized in that said active substances are in micronized form. Oral pharmaceutical composition according to claim 1, characterized in that the micronized form of the active components has an average particle size of less than 50 microns. Oral pharmaceutical composition according to claim 1, characterized in that the micronized form of the active components has a specific surface area of at least 20 · 10 cm / mg. Oral pharmaceutical composition according to any one of claims 1 to 3, characterized in that the ACE inhibitor is selected from the group consisting of ramipril, enalapril, perindopril, lisinopril, fosinopril. Oral pharmaceutical composition according to any one of claims 1 to 3, characterized in that the diuretic is selected from the group consisting of indapamide, chlortiazide, methiclotiazide, bendroflumethiazide, chlortalidone, metolazone and hydrochlorothiazide. 6. Antihypertensive drug containing an oral pharmaceutical composition according to any one of claims 1 to 3, characterized in that it contains ramipril and indapamide and, optionally, pharmaceutically acceptable excipients, mg: 7. The antihypertensive drug containing the oral pharmaceutical composition according to claim 6, characterized in that it contains ramipril and indapamide as active substances, and lactose monohydrate, silicon dioxide colloidal (aerosil), calcium stearate as auxiliary substances. An antihypertensive drug containing an oral pharmaceutical composition according to any one of claims 1-
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