Mediated by Dendritic Cell Immunoreceptors (DCIR) Cross-Priming of Human CD8 + T Cells

摘要

1. An immunostimulatory composition for generating an immune response, for prophylaxis, therapy, or any combination thereof in a human or animal object, comprising: one or more dendritic cell (DC) specific antibodies or fragments thereof, loaded or chemically linked to one or several antigenic peptides, where antigenic peptides are typical representatives of one or more epitopes of one or more antigens involved in or involved in a disease or condition against which an immune response, prophylaxis, therapy, or any combination thereof; at least one toll-like receptor (TLR) agonist selected from the group consisting of TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7 and TLR8 agonists, and pharmaceutically acceptable a carrier, where each of the conjugate and agonist is contained in such a quantity that, in combination with the other one, it is effective for eliciting an immune response, for prevention, for therapy or any combination thereof in a human object or animal object in need of immunostimulation. 2 . The composition of claim 1, wherein the composition includes one or more optional agents selected from the group consisting of an anti-CD40 agonist antibody, a CD40 agonistic antibody fragment, a CD40 ligand polypeptide (CD40L), a CD40L polypeptide fragment, an anti-4-1BB antibody, an antibody fragment 4-1BB, ligand 4-1BB polypeptide, fragment of 4-1BB ligand polypeptide, IFN-γ, TNF-α, type 1 cytokines, type 2 cytokines, or combinations and modifications thereof. 3. The composition of claim 1, wherein the DC-specific antibody or fragment is selected from an antibody that specifically binds to a dendritic cell immunoreceptor (DCIR)