COMPOUNDS OF TWO-STAIN RNAA TO RHOA AND THEIR APPLICATION

摘要

1. A double-stranded nucleic acid molecule for reducing RHOA gene expression containing a coding thread and an antisense strand, said coding thread and an antisense strand selected from an oligonucleotide designated RHOA_48 (SEQ ID NOS: 79 and 113), RHOA_48u (SEQ ID Nos: 80 and 114 ), RHOA_50 (SEQ ID No: 82 and 116) or RHOA_58 (SEQ ID No: 143 and 157), or a pharmaceutically acceptable salt of the indicated molecule. 2. The double-stranded nucleic acid molecule of claim 1, designated RHOA_48, wherein the sequence of said antisense strand contains the sequence 5 'UGUAGCAAGAUGACUUCUG 3' (SEQ ID NO: 113), and the sequence of said coding strand contains the sequence 5 'CAGAAGUCAUCUUGCUACA 3' (SEQ ID no: 79), or a pharmaceutically acceptable salt of said molecule. 3. The double-stranded nucleic acid molecule according to claim 2, which has a structure in which each sign "|" denotes base pairing; in which each of A, C, G and U independently represents an unmodified or modified ribonucleotide or non-standard group; in which each of Z and Z 'may independently be present or absent, but if present independently is 1-5 consecutive nucleotides or groups other than nucleotides or a combination of nucleotides and groups other than nucleotides covalently attached to the 3'-end of the chain in which they are present; in which z "may or may not be present, but if present, is a" capping "group covalently attached to the 5'-end of the sense strand; furthermore, said double-stranded nucleic acid molecule reduces RHOA gene expression; or a pharmaceutically acceptable salt of said molecule. 4. Molecule for