INDIRECT METHOD FOR DETERMINING THE SENSITIVITY OF LUNG CANCER CELLS cisplatin based on the level of expression of marker genes AND KIT FOR CARRYING OUT

摘要

FIELD: medicine.SUBSTANCE: presented group of inventions refers to medicine, molecular biology and biotechnology. A method for determining lung cancer cell sensitivity to cisplatin involving determining MLH1, ERCC1, DDB2, AKR1B1, FTL genes expression patterns vs. cisplatin IC50 for known cell lines; constructing cisplatin IC50 for these cell lines vs. derived gene expression patterns calibration straight, and hybridising on a microchip. What is also presented is a set of oligonucleotide probes presented by SEQ ID NO: 9-13.EFFECT: presented group of inventions provides effective aids and methods for determining lung cancer cell sensitivity to cisplatin.2 cl, 1 dwg, 2 tbl, 3 ex