METHOD FOR PREDICTION OF DETERIORATION PROBABILITY OF CLINICAL COURSE OF ATOPIC DERMATITIS, PROGRESSION OF LOCAL FORM INTO DISSEMINATED FORM, AND THEN INTO ERYTHRODERMA

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to dermatology. To predict the deterioration probability of the clinical course of atopic dermatitis, the progression of an local form of the disease into a disseminated form, and then into erythroderma, an integrated assessment of a pathoigenetic significance of the detected risk factors is made What is determined is a prognostic coefficient (PC) for such criteria, as: sex; age; living in a city, living in the countryside; financial means and living conditions; office staff; agricultural workers; construction workers; drivers; common labour personnel; hyper insolation; adverse agricultural labour conditions (pesticide and fertiliser contact); petroleum contact; construction material contact; office supplies contact; stress situations at work and in the community; drug abuse; pockets of chronic bacterial and/or mycotic infections; frequent acute respiratory viral infections; chronic gastrointestinal and/or hepatic, gall-bladder diseases; chronic respiratory infections; chronic otorhinolaryngological organs; disturbed liver detoxification; liver metabolic disturbance; circulating immune complex increase; average immunoglobulin increase; stimulation index decrease; immunoregulatory index decrease; cytotoxic index decrease; blood skin antigen; antitissue autoantibody increase; leukocyte migration inhibition index increase. If a factor is absent, the related PC is considered to be zero. The derived coefficients are summed up. If total PC is found within the range of 7.92 to 17.92, the low deterioration probability of the clinical course of atopic dermatitis and the favourable prognosis implying no progression of the local form of the disease into the disseminated form. The derived PC falling within the range of 17.93 to 37.93 shows the medium deterioration probability of the clinical course of atopic dermatitis and the possible progression of the local form of the disease into the disseminated form, with a relatively favourable prognosis with no developing erythroderma. The PC value is 37.94 to 57.94 and more enables predicting the high deterioration probability of the clinical course of the disease and the unfavourable prognosis with the possible progression of the local form of atopic dermatitis into the disseminated form, and then into erythroderma.;EFFECT: method enables predicting the deterioration probability of the clinical course of atopic dermatitis and the progression of the local form of the disease into the disseminated form, and then into erythroderma.;3 ex, 4 tbl