METHOD FOR ASSESSING PROBABILITY OF BIRTH DEFECTS IN PREGNANT WOMEN

摘要

FIELD: medicine.;SUBSTANCE: blood is sampled; a molecular-genetic analysis is used to determine genetic polymorphisms in detoxification enzyme GSTT1 in lymphocytic DNA. That is followed by an enzyme-immunoassay of immunoglobulins A and G - IgA, IgG specific to benzo[a]pyrene Bp, oestradiol Es and progesterone Pg in blood serum that are used as measurements of the body immunological response to the effect of teratogens. If observing an increase of the relations of immunoglobulins IgA Bp/Es2, IgA Bp/Pg2, IgG Bp/Es2, IgG Bp/Pg3 in GSTT1 0/0 genotype carriers, a high individual responsiveness of the pregnant woman to the effect of teratogens is stated. In this regard, a high probability of birth defects is predicted. If observing a decrease of the relations of immunoglobulins IgA Bp/Es2, IgA Bp/Pg2, IgG Bp/Es2, IgG Bp/Pg3 in GSTT1+ genotype carriers, a high individual resistance of the pregnant woman to the effect of teratogens is stated. In this regard, a low probability of birth defects is predicted.;EFFECT: more accurate and informative assessment of the probability of birth defects.;3 ex, 7 tbl