OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITIONS FOR NEOANGIOGENIC EYE PATHOLOGIES

摘要

FIELD: medicine.;SUBSTANCE: invention relates to ophthalmological pharmaceutical compositions, namely to sorafenib-based compositions, and is intended for treatment of non-cancer neoangiogenic pathologies of the eye. The invention provides application of sorafenib for production of an ophthalmological pharmaceutical composition for local, subconjunctival, subretinal or periocular introduction, for introduction by means of near-scleral injection or for introduction by means of retrobulbar injection. The said composition additionally includes VDA, corticosteroids, angiostatic cortisones, albendazole, mebendazole, carboanhydrase inhibitors (CAI), canabinoids, non-steroid anti-inflammatory drugs (NSAID), selective COX-2 inhibitors, iNOS inhibitors, molecules, interacting with inflammatory mediators, molecules with immunosuppressive action, beta-lactamines (penicillins, cephalosporins), macrolides, tetracyclines, fluoroquinolones, natural polypeptides with antibacterial activity and their fragments, SiRNA.;EFFECT: invention provides an efficient ophthalmological pharmaceutical sorafenib-based composition for treatment of non-cancer neoangiogenic pathologies of the eye.;7 cl, 2 tbl, 3 dwg, 1 ex