METHOD FOR USING IMMUNOLOGICAL MARKERS FOR PREDICTION OF PROLIFERATIONS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

摘要

FIELD: medicine.;SUBSTANCE: method for prediction of the proliferation of cervical intraepithelial neoplasias (CIN) associated with papillomavirus infection consisting in measuring a patient's blood and cervical immunological values, involves using a coefficient P, and if the coefficient P is more than 0.5, the patient is referred to a risk group of the proliferation of the disease; the coefficient P is 0.5 or less shows no risk of the proliferation of the disease. The coefficient P is calculated by means of a mathematical model: $P=\left(\frac{1}{1+e^{-\text{logotype}(P)}}\right),\mathop{\mathrm{image}}$ where logotype(P) = constant+a₁X₁+a₂X₂+…+a_nX_n, wherein Pis a probability of referring the patient to the risk group, a_iis regressioncoefficients, X_iare values included in the model.;EFFECT: improved diagnostic accuracy.;1 tbl, 2 ex