METHOD OF PRODUCING 3-METHYL-6,7-DIALKOXY-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDES BASED ON EUGENOL

摘要

FIELD: chemistry.;SUBSTANCE: present invention relates to organic chemistry and specifically to a novel method of producing 3-methyl-6,7-dialkoxy-3,4-dihydroisoquinoline hydrochlorides of general formula: , where R¹=C₂H₅, R²=H (Ia); R¹=R²=CH₃ (Ib), characterised by that the compounds I (a,b) are obtained by reacting eugenol with alkyl iodides in phase-transfer catalysis conditions (benzene/18-crown-6/KOH), followed by cyclocondensation of the formed 3,4-dialkoxy-allylbenzenes with corresponding nitriles and treating the obtained base with hydrogen chloride in an ethyl acetate medium.;EFFECT: novel method of producing dialkoxyisoquinoline derivatives, characterised by simple and readily available reactants and avoiding the use of inflammable and expensive reactants.;2 ex