STRAIN OF HYBRID CULTURED ANIMAL CELLS Mus musculus 2F9-PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC FOR LYSOSTAPHIN AND INHIBITING ITS LYTIC ACTIVITY

摘要

FIELD: biotechnology.;SUBSTANCE: new strain of hybrid cultured animal cells Mus musculus 2F9 - producer of monoclonal antibodies specific for lysostaphin inhibiting its lytic activity and suitable for its quantitation is proposed. High-affinity monoclonal antibodies (mAb) of hybridoma 2F9 enables to determine lysostaphin in the samples to the concentrations of 0.8 ng/ml. The mAb of hybridoma 2F9 can be used to study the structural and functional properties of lysostaphin and quality control of preparations based on lysostaphin.;EFFECT: improved properties.;3 dwg, 1 tbl, 5 ex