BROAD-SPECTRUM ANTIBACTERIAL PEPTIDE HOMININ KLP-1

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to biochemistry and microbiology and concerns a biologically active peptide. The characterised peptide hominin KLP-1 is produced by the strain Staphylococcus hominis KLP-1 and possesses an antibacterial activity on the representatives of the following bacterial genera: Arthrobacter, Bacillus, Corynebacterium, Enterococcus, Lactobacillus, Micrococcus, Mycobacterium, Propionibacterium, Rhodococcus, Staphylococcus, Streptococcus, it has a molecular weight of 2985 Da, is sensitive to proteases, possesses high thermal stability and has the following amino acids: 51.1% cationic and 31.7% hydrophobic amino acids, as well as a specific amino acid - lanthionine. The peptide is characterised by higher stability to heating, alkaline environment, as well as to DNAase and RNAase. The antibacterial activity of the peptide is considerably reduced or disappears in the acid environment and under the action of the enzymes pepsin, trypsin and proteinase K.;EFFECT: presented invention can find application in biotechnology, medicine, veterinary science, food industry, as well as in research studies.;1 dwg, 2 tbl, 3 ex