METHOD FOR ESTIMATING PHARMACOKINETIC PARAMETER AND ESTIMATION PROGRAM OF PHARMACOKINETIC PARAMETER

摘要

PROBLEM TO BE SOLVED: To provide a method capable of estimating a pharmacokinetic parameter while suppressing the possibility of divergence regardless of the number of pharmacokinetic parameters to be estimated.SOLUTION: The method for estimating a pharmacokinetic parameter xfrom the concentration of a drug in blood of a patient and is executed by a CPU of an electronic computer. The CPU selects a maximum likelihood method or Bayesian estimation as a method for estimating the pharmacokinetic parameter xon the basis of input data or the like in a data input screen 31. The CPU executes two-stage partial differentiation of a function s(x) of a vector x=(x, x, ..., x)of the pharmacokinetic parameter xbeing a basic formula of the maximum likelihood method or the Bayesian estimation, applies a modified Levenberg-Marquardt method to an approximate expression obtained by eliminating a term of the two-stage partial differentiation by the same pharmacokinetic parameter xfrom an expression obtained by the two-stage partial differentiation, and calculates a vector x to minimize the function s(x) to thereby estimate the pharmacokinetic parameter x.