PREVENTIVE/THERAPEUTIC AGENT OF ORAL INFECTION, AND PHARMACEUTICALS, FUNCTIONAL FOOD OR FOOD AND DRINK ADDITIVES CONTAINING PREVENTIVE/THERAPEUTIC AGENT

摘要

PROBLEM TO BE SOLVED: To provide a novel infectious gastroenteritis preventive/therapeutic agent based on an antimicrobial peptide production inducing action.SOLUTION: An oral infection preventive/therapeutic agent contains a bacterial cell of Lactobacillus plantarum KM-D2905 strain (deposition number NITE P-681). Particularly, a killed bacteria of lactic acid bacteria D2905 strain is suitable due to an excellent production inducing action of human -defensin 2 which is a defensin-type antimicrobial peptide. Prevention and treatment of infectious gastroenteritis can be performed by ingesting the bacterial cell of the lactic acid bacteria Lactobacillus plantarum KM-D2905 strain concerned. Since the preventive/therapeutic agent of the invention can be prepared in various formulations such as a tablet, the agent can be ingested readily, and can contribute to reduction of onset of oral infection, such as infectious gastroenteritis.