METHOD OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR TREATMENT, PREVENTION AND MANAGEMENT OF TUBERCULOSIS

摘要

PROBLEM TO BE SOLVED: To provide a method of treating, preventing, and managing tuberculosis and other related disorders.SOLUTION: A method comprises administering a therapeutically or prophylactically effective amount of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, in combination with an anti-tuberculosis agent. Preferably, the anti-tuberculosis agent is isoniazid or rifampin, and the PDE4 modulator is (+)-2-[1-(3-ethoxy- 4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindolin-4-yl}carboxamide, or the like.