EVALUATION METHOD OF POWDER SCATTERING STATE, TRACER MATERIAL, AND PRODUCTION METHOD OF PHARMACEUTICAL

摘要

PROBLEM TO BE SOLVED: To provide an evaluation method of a scattering state of powder including pharmaceuticals during production work of the pharmaceuticals such as pharmaceuticals with high pharmacological activity, a tracer material for use in the evaluation method, and a pharmaceutical production method using the evaluation method.;SOLUTION: (1) The evaluation method of powder scattering states includes preliminarily mixing a tracer material including a fluorescent substance in the powder in handling of the powder and monitoring the scattering state of the tracer material when handling the powder. (2) The tracer material for use in the evaluation method of powder scattering states includes an excipient and the fluorescent substance. (3) The production method of pharmaceuticals to be turned out a powdery state in a production process, includes the steps of: mixing the tracer material including the fluorescent substance in the powdery pharmaceuticals; and monitoring the scattering state of the tracer material in the production process.;COPYRIGHT: (C)2016,JPO&INPIT