Combination of bacteriophage lysin and antibiotics against gram-positive bacteria.

摘要

The present invention relates to a combination of a lysin, in particular a streptococcal lysin, in particular the lysin PlySs2, and one or more antibiotics including daptomycin, vancomycin, oxacillin, linezolid or related antibiotic (s). Provided are compositions and methods for the prevention, recovery and treatment of gram positive bacteria, particularly staphylococci, used. According to the present invention, the combination of antibiotics, including different types or classes of antibiotics, in particular daptomycin, vancomycin, linezolid or oxacillin and PlySs2 lysin, at a lower dose or lower MIC than either alone, S . It is effective in killing Gram-positive bacteria including Aureus.