Method for producing microsphere for embolization and method for producing microsphere combined with drug-containing nanotransporter

摘要

The present invention relates to a process for optimizing recoverability of freeze-dried embolic microspheres and chitosan microspheres to which drug-containing nanotransporters are bound, and more specifically, stable storage of microspheres. Before freeze-drying treatment, add trehalose as a freeze-drying protective agent, vortex the freeze-dried microspheres and rehydrate the recovery optimization process and drug / chitosan The present invention relates to a microsphere capable of precisely controlling drug release since the amount of the drug released from the chitosan microsphere to which the drug-containing nanotransporter is bound is adjusted depending on the ratio, and a method for producing the microsphere. The optimization process according to the present invention has the advantage that the physical properties, morphology and degree of drug release can be maintained even after freeze-drying of embolic microspheres, and the drug-containing nanotransporter according to the present invention is bound. Chitosan microspheres can be used for chemotherapy (anticancer drug treatment) because they stably embolize in blood vessels and the drug release is precisely regulated. [Selection] Figure 9