Long-acting oxyntomodulin variants and methods for their preparation

摘要

The present invention relates to chorionic gonadotropin carboxy-terminal peptide (CTP) modified GLP-1 / glucagon dual receptor agonists and methods for making and using the same. In one embodiment, the present invention provides a CTP-modified polypeptide comprising a GLP-1 / glucagon dual receptor agonist and at least one chorionic gonadotropin carboxy terminal peptide (CTP) linked to the amino terminus or carboxy terminus of said agonist. provide. [Selection] Figure 5A