Transpulmonary delivery of mRNA to non-pulmonary target cells

摘要

A composition comprising mRNA formulated for pulmonary administration and related methods for delivery of mRNA and / or encoded protein to non-pulmonary cells or tissues. The compositions and methods can be used to prevent or ameliorate symptoms of diseases associated with the protein encoded by the mRNA. The present invention provides a method for delivering mRNA gene therapeutics using non-invasive pulmonary administration. In particular, the present invention provides mRNA delivery encoding proteins that can be used in methods for the treatment and / or prevention of diseases. [Selection] Figure 12