AQUEOUS-CORE LIPID NANOCAPSULE FOR ENCAPSULATING HYDROPHILIC AND/OR LIPOPHILIC MOLECULE

摘要

PROBLEM TO BE SOLVED: To provide nano-assemblies forming aqueous-core reservoir nanocapsules which are particularly useful for the encapsulation and the delivery of hydrophilic or lipophilic species, notably of fragile drugs and which enable simultaneously the encapsulation of hydrophilic species in the aqueous core and of lipophilic species in the lipid shell with high yields.SOLUTION: The invention relates to a composition comprising in an aqueous phase, particles (P) each having a diameter in the range of 20 to 500 nm, the particles (P) containing: an oil phase; in the oil phase, an aqueous droplet, or a nanocapsule (NC) comprising: an aqueous core, and a polymeric shell or a shell composed of an amphiphilic substance; and a surfactant.