New oxysterol analog OXY149 induces bone development and hedgehog signaling, inhibits adipogenesis

摘要

The present invention relates to, for example, a synthetic compound Oxy149 having the structure (Formula I), or a physiologically active or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Also disclosed are methods for treating various disorders using this compound or bioactive composition or pharmaceutical composition including, for example, bone disorders, obesity, cardiovascular disorders and neurological disorders. Oxy149 can be delivered locally or systemically.